Blar i forfatter "Szafranska, Karolina Joanna"

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    • Grazing incidence to total internal reflection fluorescence structured illumination microscopy enabled by a prism telescope 

      Ortkrass, Henning; Wiebusch, Gerd; Linnenbrügger, Jochen; Schürstedt, Jasmin; Szafranska, Karolina Joanna; McCourt, Peter Anthony; Huser, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-13)
      In super-resolution structured illumination microscopy (SR-SIM) the separation between opposing laser spots in the back focal plane of the objective lens affects the pattern periodicity, and, thus, the resulting spatial resolution. Here, we introduce a novel hexagonal prism telescope which allows us to seamlessly change the separation between parallel laser beams for 3 pairs of beams, simultaneously. ...

    • High-speed TIRF and 2D super-resolution structured illumination microscopy with a large field of view based on fiber optic components 

      Ortkrass, Henning; Schürstedt, Jasmin; Wiebusch, Gerd; Szafranska, Karolina Joanna; McCourt, Peter Anthony; Huser, Thomas Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)
      Super-resolved structured illumination microscopy (SR-SIM) is among the most flexible, fast, and least perturbing fluorescence microscopy techniques capable of surpassing the optical diffraction limit. Current custom-built instruments are easily able to deliver two-fold resolution enhancement at video-rate frame rates, but the cost of the instruments is still relatively high, and the physical size ...

    • Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2 

      Holte, Christopher Florian; Szafranska, Karolina Joanna; Kruse, Larissa Dorothea; Simon-Santamaria, Jaione; Li, Ruomei; Svistounov, Dmitri; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-05)
      Oxidized albumin (oxHSA) is elevated in several pathological conditions, such as decompensated cirrhosis, acute on chronic liver failure and liver mediated renal failure. Patient derived oxidized albumin was previously shown to be an infammatory mediator, and in normal serum levels of oxHSA are low. The removal from circulation of oxidized albumins is therefore likely required for maintenance of ...